The impact of High Performance Work Systems (HPWS) on performance and staff retention in Pakistani business schools was examined in this study. It specifically looked into the effects on faculty members' performance when HPWS methods are used. Additionally, the study investigated how" Employee Turnover" mediated the association between HPWS and performance. Based on the Job Demand-Resource Model's (JD-R) theoretical framework, the study developed a model and evaluated some hypotheses. Questionnaires from 17 universities in Islamabad and Rawalpindi, which included 251 faculty members from different Pakistani business schools, were used for data gathering. The main tool for data analysis was SPSS version 24, which is the Statistical Package for Social Sciences.